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To assess the efficacy of educational intervention and to develop new Cd C oriented programs of rehabilitation, it is important to describe their developmental steps.

In fact, developmental charts have been developed (gross motor, fine motor, speech, and personal/social) collecting data from 84 Italian patients [4].

Using data on the development of a group of Cd C patients obtained by validated Italian translation for the Denver Developmental Screening Test II, we compared a group of 13 patients undergoing an educational program developed for Cd C patients, the Mayer Project (MP), with a second group of 15 cases in whom caring was not specifically oriented.

A positive impact of the MP was reported by parents, observing an improvement in social skills obtained, even if no significant differences were observed when the items of the Denver Test are studied.

Touch included wiping, superficial touching, rubbing, kneading, and vibration stimuli.Main clinical features include high-pitched cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, and severe psychomotor retardation. A molecular cytogenetic map of the deletion has been tentatively established [1].As the degree of mental retardation is significant, it causes relevant problems in caring for the patients.The ED offered to contact the families twice a year, for a 2–4-day home visit first, followed after 6 months by evaluation of the compliance to the given suggestions.During the first visit, the ED evaluated the management of patients (by their families and different local operators, as nurses, physiotherapists, speech therapists, teacher, professional educator, etc.) as related to motor development and training for everyday social life.

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